4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

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Chemical Name:4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide
CAS No.:1618664-03-1
Molecular Formula:C₂₈H₃₆ClN₇O₃Si
Molecular Weight:582.177
Hs Code.:

4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

Synonyms:4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

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Chemical Property of 4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

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Technology Process of 4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

There total 5 articles about 4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 406188-95-2
5-chloro-1-methyl-1H-pyrazol-4-amine hydrochloride

: 1618663-59-4
4-(2-chloro-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

: 1618664-03-1
4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine; caesium carbonate; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

: 1012785-51-1
2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

: 1618664-03-1
4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 30 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 2 h / 80 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine; caesium carbonate / 1,4-dioxane / 16 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1404364-72-2
2,4-dichloro-5-iodo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

: 1618664-03-1
4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-4-cyclobutoxy-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 30 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 2 h / 80 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine; caesium carbonate / 1,4-dioxane / 16 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; mineral oil;