5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate
CAS No.:161762-46-5
Molecular Formula:C₆₃H₆₆N₅O₁₆P
Molecular Weight:1180.21
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 593-56-6
N-methoxylamine hydrochloride

: 157793-51-6,165879-39-0,165879-40-3
3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl ethyl phosphonate

: 161762-46-5
5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate

Guidance literature:: With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrachloromethane;
DOI:10.1080/15257779508012534

Reference yield:

: 161762-46-5
5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate

: 5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(O-cyanoethyl-N,N-diisopropylphosphoramidite)-5'-thymidine-N-methoxyphosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / AcOH, H₂O / 3.5 h / Ambient temperature

2: 66 percent / pyridine / 4 h / Ambient temperature

3: 50 percent / diisopropyl amminoium tetrazolide / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; N,N-diisopropylamine tetrazolide; water; acetic acid; In dichloromethane;
DOI:10.1080/15257779408013213

Reference yield:

: 161762-46-5
5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-3'-O-(4,4'-dimethoxytrityl)-5'-thymidine-N-methoxyphosphoramidate

: 161762-48-7
5'-O-(4,4'-dimethoxytrityl)-3'-thymidine-5'-thymidine-N-methoxyphosphoramidate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / AcOH, H₂O / 3.5 h / Ambient temperature

2: 66 percent / pyridine / 4 h / Ambient temperature

With pyridine; water; acetic acid;
DOI:10.1080/15257779408013213