Technology Process of N4-[(1S)-2-((1S)-1-[(benzyloxy)methyl]-2,3-dioxo-3-[(1,1,3,3-tetramethylbutyl)amino]propylamino)-1-(cyclohexylmethyl)-2-oxoethyl]-4-morpholinecarboxamide
There total 7 articles about N4-[(1S)-2-((1S)-1-[(benzyloxy)methyl]-2,3-dioxo-3-[(1,1,3,3-tetramethylbutyl)amino]propylamino)-1-(cyclohexylmethyl)-2-oxoethyl]-4-morpholinecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N4-[(1S)-2-((1S)-1-[(benzyloxy)methyl]-2-hydroxy-3-oxo-3-[(1,1,3,3-tetramethylbutyl)amino]propylamino)-1-(cyclohexylmethyl)-2-oxoethyl]-4-morpholinecarboxamide;
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 2h;
With
sodium thiosulfate;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / -20 °C
1.2: 0.5 h / Cooling with ice
2.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
3.1: dichloromethane / 48 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 0.5 h
5.1: triethylamine / N,N-dimethyl-formamide / Inert atmosphere
6.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
With
4-methyl-morpholine; Dess-Martin periodane; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
In
1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
3.1: Passerini Reaction;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
1.2: 25 °C / Inert atmosphere
2.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / -20 °C
2.2: 0.5 h / Cooling with ice
3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
4.1: dichloromethane / 48 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.5 h
6.1: triethylamine / N,N-dimethyl-formamide / Inert atmosphere
7.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
With
4-methyl-morpholine; sodium hydride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
In
1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
4.1: Passerini Reaction;