1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid
CAS No.:1396007-33-2
Molecular Formula:C₂₈H₂₅FN₄O₄
Molecular Weight:500.529
Hs Code.:

Synonyms:1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

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Chemical Property of 1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

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Technology Process of 1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

There total 11 articles about 1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid methyl ester

: 1396007-33-2
1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 11h;

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1396007-33-2
1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide; copper diacetate / methanol / 23 h / 20 °C

2: toluene / 4.5 h / 150 °C

3: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

4: triethylamine; diphenyl phosphoryl azide / toluene / 6 h / 80 °C / Inert atmosphere

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 4 h / 100 °C / Inert atmosphere

6: water; lithium hydroxide / tetrahydrofuran / 11 h / 60 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; sodium azide; diphenyl phosphoryl azide; water; copper diacetate; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene; 5: |Suzuki Coupling;

Reference yield:

: 2101-88-4
1-azido-4-bromobenzene

: 1396007-33-2
1-(4'-{5-[(R)-1-(2-fluoro-phenyl)-ethoxycarbonylamino]-4-methyl-[1,2,3]triazol-1-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 4.5 h / 150 °C

2: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

3: triethylamine; diphenyl phosphoryl azide / toluene / 6 h / 80 °C / Inert atmosphere

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 4 h / 100 °C / Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran / 11 h / 60 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; diphenyl phosphoryl azide; water; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; water; toluene; 4: |Suzuki Coupling;