3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Base Information

Chemical Name:3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one
CAS No.:1238701-69-3
Molecular Formula:C₁₇H₁₆F₃N₃O₃
Molecular Weight:367.328
Hs Code.:

Synonyms:3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

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Chemical Property of 3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

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Technology Process of 3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

There total 6 articles about 3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1238701-66-0
3-acetyl-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1238701-69-3
3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Guidance literature:: for 3h; Reflux;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1238701-69-3
3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.25 h / 0 °C

1.2: 0 °C

2.1: 4 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; trimethylaluminum / toluene; dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

4.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

5.1: 3 h / Reflux

With hydrogenchloride; trimethylaluminum; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; 4.1: |Grignard Reaction;
DOI:10.1021/jm5013648

Reference yield:

: 1238701-62-6
methyl 5-methoxy-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate

: 1238701-69-3
3-[3-(dimethylamino)prop-2-enoyl]-5-methoxy-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; trimethylaluminum / toluene; dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

3.1: 3 h / Reflux

With trimethylaluminum; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 2.1: |Grignard Reaction;
DOI:10.1021/jm5013648