methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Base Information

Chemical Name:methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate
CAS No.:141046-42-6
Molecular Formula:C₂₃H₂₄FN₃O₃
Molecular Weight:409.46
Hs Code.:

methyl <S-(E)>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Synonyms:methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

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Technology Process of methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

There total 10 articles about methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 124-41-4
sodium methylate

: 141046-41-5
2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

: 141046-42-6
methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Guidance literature:: In methanol; for 16h;
DOI:10.1021/jm00089a022

Reference yield:

: 114433-94-2
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

: 141046-42-6
methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

6: 81 percent / methanol / 16 h

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In methanol; formic acid; acetic acid;
DOI:10.1021/jm00089a022

Reference yield:

: 4930-98-7
pyrid-2-ylhydrazine

: 141046-42-6
methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

6: 81 percent / methanol / 16 h

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In methanol; formic acid; acetic acid;
DOI:10.1021/jm00089a022