(1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

Base Information

Chemical Name:(1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester
CAS No.:145450-34-6
Molecular Formula:C₂₃H₃₃NO₂
Molecular Weight:355.521
Hs Code.:

Synonyms:(1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

There total 3 articles about (1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 145449-95-2
endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate

: 145450-34-6
(1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 4h; under 760 Torr; Ambient temperature;
DOI:10.1016/0223-5234(92)90179-5

Reference yield:

: 3423-25-4
endo-8-(1-methylethyl)-8-azabicyclo<3.2.1>octan-3-ol

: 145450-34-6
(1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / triethylamine / 1,2-dichloro-ethane / 9 h / Heating

2: 84 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 760 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;
DOI:10.1016/0223-5234(92)90179-5

Reference yield:

: 145450-39-1
2-phenyl-2-cyclohexene-1-carbonyl chloride

: 145450-34-6
(1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / triethylamine / 1,2-dichloro-ethane / 9 h / Heating

2: 84 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 760 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;
DOI:10.1016/0223-5234(92)90179-5