1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine

Base Information

Chemical Name:1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine
CAS No.:1439393-26-6
Molecular Formula:C₂₃H₂₀N₈
Molecular Weight:408.465
Hs Code.:

Synonyms:1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine

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Chemical Property of 1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine

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Technology Process of 1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine

There total 5 articles about 1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439393-28-8
tert-butyl 1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutylcarbamate

: 1439393-26-6
1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1439393-21-1
tert-butyl 1-(4-(2-chloro-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutylcarbamate

: 1439393-26-6
1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 2 h / 0 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 1259224-00-4
[1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

: 1439393-26-6
1-(4-(2-(1H-pyrazol-4-yl)-8-(pyridin-2-yl)-9H-purin-9-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: hydrogen / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: copper diacetate; acetic acid / 2 h / 80 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

5: hydrogenchloride / ethyl acetate / 2 h / 0 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen; copper diacetate; caesium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;