6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile

Base Information

• Chemical Name: 6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile
• CAS No.: 1214320-25-8
• Molecular Formula: C₁₆H₁₁ClN₄O
• Molecular Weight: 310.743
• Mol file: 1214320-25-8.mol

Synonyms:6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile

Chemical Property of 6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile

There total 1 articles about 6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(3-chloro-4-hydroxyphenyl)boronic acid (182344-13-4) + C10H7BrN4 (1032822-31-3) → 6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile (1214320-25-8)

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In ethanol; water; at 120 ℃; Microwave irradiation;

DOI:10.1021/jm901705h

Reference yield: 82.0%

6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile (1214320-25-8) → 2'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-5'-cyanobiphenyl-4-yl sulfamate (1214320-26-9)

Guidance literature:

With sulphamoyl chloride; In N,N-dimethyl acetamide; at 20 ℃; Cooling with ice;

DOI:10.1021/jm901705h

upstream raw materials:

(3-chloro-4-hydroxyphenyl)boronic acid

C₁₀H₇BrN₄

Downstream raw materials:

2'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-5'-cyanobiphenyl-4-yl sulfamate