2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

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Chemical Name:2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one
CAS No.:1233361-64-2
Molecular Formula:C₂₂H₂₂N₆O₄
Molecular Weight:434.454
Hs Code.:

Synonyms:2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

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Chemical Property of 2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

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Technology Process of 2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

There total 8 articles about 2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1100598-44-4
2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

: 96-24-2
3-monochloro-1,2-propanediol

: 1233361-64-2
2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

Guidance literature:: With caesium carbonate; In acetone; at 80 ℃; for 120h;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1233361-64-2
2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate tribasic trihydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

2.1: thionyl chloride / dichloromethane / 3 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: potassium acetate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Inert atmosphere

4.2: 18 h / 70 °C / Inert atmosphere

5.1: water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

5.2: pH 1

6.1: caesium carbonate / acetone / 120 h / 80 °C

With thionyl chloride; potassium phosphate tribasic trihydrate; water; potassium acetate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1100598-50-2
5-bromo-2-(3-chloromethyl-phenyl)-pyrimidine

: 1233361-64-2
2-{3-[5-(2,3-dihydroxypropoxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: potassium acetate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Inert atmosphere

2.2: 18 h / 70 °C / Inert atmosphere

3.1: water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3.2: pH 1

4.1: caesium carbonate / acetone / 120 h / 80 °C

With water; potassium acetate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;