(1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine

Base Information

Chemical Name:(1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine
CAS No.:1379686-18-6
Molecular Formula:C₁₃H₂₂N₄O
Molecular Weight:250.344
Hs Code.:

(1R,2R)-N<sub>1</sub>-(4-methoxypyrimidin-2-yl)-N<sub>2</sub>,N<sub>2</sub>-dimethylcyclohexane-1,2-diamine

Synonyms:(1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine

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Chemical Property of (1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine

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Technology Process of (1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine

There total 3 articles about (1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 22536-63-6
2-chloro-4-methoxypyrimidine

: 320778-92-5
(1R,2R)-N,N-dimethylcyclohexane-1,2-diamine

: 1379686-18-6
(1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine

Guidance literature:: With sodium carbonate; In ethanol; for 24h; Reflux; Inert atmosphere;
DOI:10.1002/ejoc.201200118

Reference yield:

: 877677-96-8
N-[(1R,2R)-2-(dimethylamino)cyclohexyl]benzamide

: 1379686-18-6
(1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / Reflux; Inert atmosphere

2: sodium hydroxide / dichloromethane / Inert atmosphere

3: sodium carbonate / ethanol / 24 h / Reflux; Inert atmosphere

With hydrogenchloride; sodium carbonate; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1002/ejoc.201200118

Reference yield:

: 1234860-01-5,1263285-80-8
(1R,2R)-N₁,N₁-dimethylcyclohexane-1,2-diamine bishydrochloride

: 1379686-18-6
(1R,2R)-N₁-(4-methoxypyrimidin-2-yl)-N₂,N₂-dimethylcyclohexane-1,2-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane / Inert atmosphere

2: sodium carbonate / ethanol / 24 h / Reflux; Inert atmosphere

With sodium carbonate; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201200118