3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole

Base Information

• Chemical Name: 3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole
• CAS No.: 1418132-00-9
• Molecular Formula: C₁₉H₁₂F₄N₂O₂
• Molecular Weight: 376.31
• Mol file: 1418132-00-9.mol

Synonyms:3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole

Chemical Property of 3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole

Chemical Property:

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Technology Process of 3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole

There total 1 articles about 3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one (75175-77-8) + 2-oxo-N-(4-(trifluoromethyl)phenyl)propanehydrazonoyl chloride → 3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole (1418132-00-9)

Guidance literature:

In neat (no solvent); at 120 ℃; for 0.1h; Time; regioselective reaction; Catalytic behavior; Microwave irradiation; Green chemistry;

DOI:10.1016/j.molcata.2012.11.009

Reference yield: 88.0%

3-acetyl-4-(4-fluorobenzoyl)-1-(4-trifluoromethylphenyl)pyrazole (1418132-00-9) → 4-(4-fluorophenyl)-7-methyl-2-(4-(trifluoromethyl)phenyl)-2H-pyrazolo[3,4-d]pyridazine (1418132-05-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 120 ℃; for 0.05h; Time; Temperature; Microwave irradiation;

DOI:10.1016/j.molcata.2012.11.009

upstream raw materials:

3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one

Downstream raw materials:

4-(4-fluorophenyl)-7-methyl-2-(4-(trifluoromethyl)phenyl)-2H-pyrazolo[3,4-d]pyridazine