{(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

Base Information

Chemical Name:{(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine
CAS No.:120059-84-9
Molecular Formula:C₂₀H₂₅N₃O₂
Molecular Weight:339.437
Hs Code.:

Synonyms:{(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

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Chemical Property of {(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

Chemical Property:

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Technology Process of {(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

There total 4 articles about {(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 120143-74-0
(3R,4R)-(-)-trans-3-methyl-N-phenyl-4-piperidinamine

: 120059-84-9
{(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

Guidance literature:: With sodium carbonate; potassium iodide; In various solvent(s); Heating;
DOI:10.1021/jm00126a040

Reference yield:

: 31633-72-4
methyl 3-methyl-4-oxo-1-piperidinecarboxylate

: 120059-84-9
{(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / p-toluene sulfonic acid / toluene / Heating

2: 1.) sodium metal, 2.) 48 percent HBr / 1.) methanol, reflux, 2.) reflux, 4 h

3: 62 percent / Na₂CO₃, KI / various solvent(s) / Heating

With hydrogen bromide; sodium; sodium carbonate; toluene-4-sulfonic acid; potassium iodide; In toluene;
DOI:10.1021/jm00126a040

Reference yield:

: 62-53-3
aniline

: 120059-84-9
{(3R,4R)-3-Methyl-1-[2-(4-nitro-phenyl)-ethyl]-piperidin-4-yl}-phenyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / p-toluene sulfonic acid / toluene / Heating

2: 1.) sodium metal, 2.) 48 percent HBr / 1.) methanol, reflux, 2.) reflux, 4 h

3: 62 percent / Na₂CO₃, KI / various solvent(s) / Heating

With hydrogen bromide; sodium; sodium carbonate; toluene-4-sulfonic acid; potassium iodide; In toluene;
DOI:10.1021/jm00126a040