Technology Process of (R)-1-(2-(4-(4-fluorophenoxy)phenoxy)ethyl)-2-methylpyrrolidine
There total 5 articles about (R)-1-(2-(4-(4-fluorophenoxy)phenoxy)ethyl)-2-methylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate; potassium iodide;
In
acetonitrile;
at 85 ℃;
for 48h;
Inert atmosphere;
Schlenk technique;
DOI:10.1039/c3ra46392c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: copper(l) iodide; tetrabutylammomium bromide; potassium phosphate / N,N-dimethyl-formamide / 22 h / Inert atmosphere; Schlenk technique; Reflux
2: hydrogen bromide; acetic acid / 16 h / Inert atmosphere; Schlenk technique; Reflux
3: potassium carbonate / acetonitrile / 45 h / Inert atmosphere; Schlenk technique; Reflux
4: potassium carbonate; potassium iodide / acetonitrile / 48 h / 85 °C / Inert atmosphere; Schlenk technique
With
potassium phosphate; copper(l) iodide; tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; acetic acid; potassium iodide;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ra46392c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen bromide; acetic acid / 16 h / Inert atmosphere; Schlenk technique; Reflux
2: potassium carbonate / acetonitrile / 45 h / Inert atmosphere; Schlenk technique; Reflux
3: potassium carbonate; potassium iodide / acetonitrile / 48 h / 85 °C / Inert atmosphere; Schlenk technique
With
hydrogen bromide; potassium carbonate; acetic acid; potassium iodide;
In
acetonitrile;
DOI:10.1039/c3ra46392c
