26129-34-0

Upstream product

• 150-76-5 4-methoxy-phenol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 371-41-5 4-Fluorophenol 
• 352-34-1 4-fluoro-1-iodobenzene 
• 100-17-4 para-methoxynitrobenzene 
• 696-62-8 para-iodoanisole 

Downstream Products

• 1524-19-2 4-(4-fluorophenoxy)phenol 
• 1610838-92-0 2-iodo-4-(4-fluorophenoxy)phenol 
• 1610838-95-3 (R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine 
• 179020-10-1 1-(4-(3-chloropropoxy)phenoxy)-4-fluorobenzene 
• 1450804-87-1 1-(4-(2-chloroethoxy)phenoxy)-4-fluorobenzene 
• 1450804-92-8 (R)-1-(3-(4-(4-fluorophenoxy)phenoxy)propyl)-2-methylpyrrolidine 
• 1450804-93-9 (R)-1-(2-(4-(4-fluorophenoxy)phenoxy)ethyl)-2-methylpyrrolidine 

Relevant academic research and scientific papers

Pd-Catalyzed Etherification of Nitroarenes

The Pd-catalyzed etherification of nitroarenes with arenols has been achieved using a new rationally designed ligand. Mechanistic insights were used to design the ligand so that both the oxidative addition and reductive elimination steps of a plausible catalytic cycle were facilitated. The catalytic system established here provides direct access to a range of unsymmetrical diaryl ethers from nitroarenes.

Aromatic diamine monomer and preparation method thereof

The invention provides an aromatic diamine monomer. The aromatic diamine monomer has a structure shown as formula (V), in the formula (V), R1 is selected from alkyl, substituted alkyl, phenyl or substituted phenyl; R2 and R3 are independently selected fro

Identification of an Oxalamide Ligand for Copper-Catalyzed C?O Couplings from a Pharmaceutical Compound Library

A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that is generally effective for copper-catalyzed C?O cross-couplings to prepare both biarylethers as well as phenols under mild conditions.

Synthesis and biological evaluation of XB-1 analogues as novel histamine H3 receptor antagonists and neuroprotective agents

A novel class of H3 receptor antagonists, XB-1 analogues based on benzophenone or oxydibenzene scaffolds were synthesized, and their biological activities were evaluated to determine their in vitro neuroprotective effects against Aβ25-35-induced damage in primary cortical neurons and against glutamate-induced neuronal injury in primary cerebellar granule neurons. The results indicated that all of the tested analogues displayed neuroprotective activity at 0.1 μM or 1 μM. These findings may provide new insights into the development of novel promising H3 receptor antagonists with potential neuroprotective activity.

An Ullmann C-O coupling reaction catalyzed by magnetic copper ferrite nanoparticles

Herein, an efficient method for the Ullmann C-O coupling reaction between various kinds of phenols and aryl halides, including amino, ketone, cyano, methyl, methoxy, fluoro, chloro and bromo derivatives, is described. The catalyst used, copper ferrite (CuFe2O4) nanoparticles, are easily made, air-stable, and of low cost. The catalyst can be recycled easily just by using an external magnet. Even in the presence of sensitive substituents, the reaction proceeds successfully to provide the desired products in high yields without protection of other functional groups. Copyright

Copper(I) Phenoxide complexes in the etherification of aryl halides

"Chemical Equation Presented" No copping out! Copper(I) phenoxide complexes containing chelating ligands (see picture), proposed intermediates in copper-catalyzed etherification of aryl halides, have been synthesized and fully characterized. The kinetic and chemical competence of the isolated complexes are demonstrated for the synthesis of aryl phenyl ethers, and experiments provide evidence against mechanistic pathways involving the formation of either free or caged radicals.

(2-Pyridyl)acetone-promoted Cu-catalyzed O-arylation of phenols with aryl iodides, bromides, and chlorides

(Chemical Equation Presented) Employing (2-pyridyl)acetone as a new supporting ligand, the copper-catalyzed coupling reactions of aryl chlorides, aryl bromides, and aryl iodides with various phenols successfully proceeded in good yields under mild conditions. This reaction displays great functional groups compatibility and excellent reactive selectivity.

Ullmann diaryl ether synthesis: rate acceleration by 2,2,6,6-tetramethylheptane-3,5-dione.

[reaction: see text]. In the copper salt catalyzed ether formation from aryl bromides or iodides and phenols, 2,2,6,6-tetramethylheptane-3,5-dione (TMHD) was found to greatly accelerate the ordinarily difficult reaction, making it occur under more moderate temperatures and reaction times. A series of aryl halides and phenols were shown to form ethers in NMP as the solvent, cesium carbonate as the base, and CuCl and TMHD as the catalysts. The reaction was shown to tolerate electron-rich aryl bromides and electron-neutral phenols.

LTA4 Hydrolase inhibitors

The present invention provides compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as proriasis, ulcerative colitis, IBD and asthma.