2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

Base Information

Chemical Name:2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride
CAS No.:1350522-71-2
Molecular Formula:C₁₆H₁₅ClN₄O₂*ClH
Molecular Weight:367.235
Hs Code.:

Synonyms:2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

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Chemical Property of 2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

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Technology Process of 2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

There total 4 articles about 2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1278416-49-1
tert-butyl 2-(2-chlorophenyl)-1,5-dioxo-2,3,5,8,9,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-10(7H)-carboxylate

: 1350522-71-2
2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2011.10.016

Reference yield:

: 1350522-88-1
methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

: 1350522-71-2
2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 1 h / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

3: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; sodium methylate; sodium hydrogencarbonate; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.10.016

Reference yield:

: 1350522-89-2
C₁₇H₁₉ClN₄O₃

: 1350522-71-2
2-(2-chlorophenyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

2: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; sodium methylate; sodium hydrogencarbonate; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.10.016