methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

Base Information

• Chemical Name: methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate
• CAS No.: 1350522-88-1
• Molecular Formula: C₁₄H₁₂Cl₂N₂O₄
• Molecular Weight: 343.166
• Mol file: 1350522-88-1.mol

Synonyms:methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

Chemical Property of methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

There total 4 articles about methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-1,1,1-triethoxyethane (51076-95-0) + methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate (1158233-60-3) → methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate (1350522-88-1)

Guidance literature:

With acetic acid; In acetonitrile; at 70 ℃; Inert atmosphere;

Reference yield:

2-chloro-1,1,1-triethoxyethane (51076-95-0) + C12H11ClN2O3 (1158589-04-8) → methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate (1350522-88-1)

Guidance literature:

With acetic acid; In acetonitrile; at 70 ℃; Inert atmosphere;

DOI:10.1021/jm100773e

Reference yield:

(2-chlorophenyl)hydrazine (10449-07-7) → methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate (1350522-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 130 - 140 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 46 h / 140 °C

3: acetic acid / acetonitrile / 70 °C / Inert atmosphere

With acetic acid; N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile;

upstream raw materials:

2-chloro-1,1,1-triethoxyethane

C₁₂H₁₁ClN₂O₃

methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

3-oxopentanedioic acid dimethyl ester

Downstream raw materials:

methyl [(4Z)-4-(4-benzyl-1,4-diazepan-2-ylidene)-1-(2-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate

10-benzyl-2-(2-chlorophenyl)-2,3,8, 9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione

2-(2-chlorophenyl)-10-(pyridin-3-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride

2-(2-chlorophenyl)-10-(pyridin-2-ylmethyl)-2,3,8,9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione hydrochloride