2-BROMO-4-HYDROXYPHENYLACETIC ACID

Base Information

• Chemical Name: 2-BROMO-4-HYDROXYPHENYLACETIC ACID
• CAS No.: 88491-44-5
• Molecular Formula: C8H7 Br O3
• Molecular Weight: 231.046
• Hs Code.: 2918290000
• Mol file: 88491-44-5.mol

Synonyms:2-Bromo-4-hydroxyphenylaceticacid

Chemical Property of 2-BROMO-4-HYDROXYPHENYLACETIC ACID

Chemical Property:

• Boiling Point: 394.6±27.0 °C(Predicted)
• PKA: 4.26±0.10(Predicted)
• PSA: 57.53000
• Density: 1.757±0.06 g/cm3(Predicted)
• LogP: 1.78180

Purity/Quality:

95% ^*data from raw suppliers

2-Bromo-4-hydroxyphenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-HYDROXYPHENYLACETIC ACID

There total 3 articles about 2-BROMO-4-HYDROXYPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

2-(2-bromo-4-hydroxyphenyl)-2-hydroxyacetic acid → 2-(2-bromo-4-hydroxyphenyl)acetic acid (88491-44-5)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; at 80 ℃; for 3h; Reagent/catalyst; Temperature;

Reference yield:

2-(2-bromo-4-(methoxy)phenyl)acetic acid (66916-99-2) → 2-(2-bromo-4-hydroxyphenyl)acetic acid (88491-44-5)

Guidance literature:

2-(2-bromo-4-(methoxy)phenyl)acetic acid; With boron tribromide; In dichloromethane; for 3h; Reflux;

With water; In dichloromethane; Cooling with ice;

Reference yield:

3-Bromophenol (591-20-8) → 2-(2-bromo-4-hydroxyphenyl)acetic acid (88491-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 8 h / 40 °C

2: tin(II) chloride dihdyrate; hydrogenchloride / 3 h / 80 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sodium hydroxide; In water;

upstream raw materials:

2-(2-bromo-4-(methoxy)phenyl)acetic acid

3-Bromophenol

Downstream raw materials:

methyl 2-bromo-4-hydroxyphenylacetate

cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate

2-(2-bromo-4-hydroxyphenyl)-N-methoxy-N-methylacetamide

[2-bromo-4-(cyclopropylmethoxy)phenyl]acetic acid