Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate

Base Information

Chemical Name:Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate
CAS No.:153109-87-6
Molecular Formula:C₃₀H₄₃NO₅S₂Si
Molecular Weight:589.893
Hs Code.:

Synonyms:Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate

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Chemical Property of Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate

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Technology Process of Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate

There total 8 articles about Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 540-63-6
ethane-1,2-dithiol

: (2S,3R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2-formyl-3-methoxymethoxy-piperidine-1-carboxylic acid methyl ester

: 153109-87-6
Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate

Guidance literature:: With 3 A molecular sieve; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: 144463-07-0
Methyl (-)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-hydroxymethyl-3-(methoxymethoxy)piperidine-1-carboxylate

: 153109-87-6
Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / PCC, AcONa / CH₂Cl₂ / 3 h / Ambient temperature

2: 68 percent / 3 Angstroem molecular sieves, BF₃*Et₂O / CH₂Cl₂ / 3 h / 0 °C

With 3 A molecular sieve; boron trifluoride diethyl etherate; sodium acetate; pyridinium chlorochromate; In dichloromethane;

Reference yield:

: 144463-12-7
Dimethyl (+)-3-acetoxy-6-(2-hydroxyethyl)piperidine-1,2-dicarboxylate

: 153109-87-6
Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

2: K₂CO₃ / methanol / 0.83 h / Ambient temperature

3: i-Pr₂EtN / CHCl₃ / 2 h / Heating

4: 87 percent / Super-Hydride / tetrahydrofuran / 0.5 h / Ambient temperature

5: 93 percent / PCC, AcONa / CH₂Cl₂ / 3 h / Ambient temperature

6: 68 percent / 3 Angstroem molecular sieves, BF₃*Et₂O / CH₂Cl₂ / 3 h / 0 °C

With dmap; 3 A molecular sieve; boron trifluoride diethyl etherate; sodium acetate; lithium triethylborohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; chloroform;