144463-07-0

Upstream product

• 194228-04-1 Dimethyl (-)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate 
• 194227-99-1 Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 144463-13-8 Dimethyl (+)-3-acetoxy-6-<2-(tert-butyldiphenylsilyloxy)ethyl>piperidine-1,2-dicarboxylate 
• 144463-12-7 Dimethyl (+)-3-acetoxy-6-(2-hydroxyethyl)piperidine-1,2-dicarboxylate 
• 144463-13-8 Dimethyl (-)-3-acetoxy-6-<2-(tert-butyldiphenylsilyloxy)ethyl>piperidine-1,2-dicarboxylate 
• 1054636-05-3 (2R,3S,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-hydroxy-piperidine-1,2-dicarboxylic acid dimethyl ester 
• 144463-12-7 (2R,3S,6S)-3-Acetoxy-6-(2-hydroxy-ethyl)-piperidine-1,2-dicarboxylic acid dimethyl ester 

Downstream Products

• 1026460-58-1 (2R,3S,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2-formyl-3-methoxymethoxy-piperidine-1-carboxylic acid methyl ester 
• 153109-93-4 Methyl (-)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate 
• 5227-24-7 (2S,5R,6R)-12-(5-hydroxy-6-methyl-piperidin-2-yl)-dodecan-2-one 
• 144463-14-9 Methyl 6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)-2-methylpiperidine-1-carboxylate 
• 153109-87-6 Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-(1,3-dithiolan-2-yl)-3-(methoxymethoxy)piperidine-1-carboxylate 
• 194228-05-2 (2S,3S,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-methoxymethoxy-2-methyl-piperidine-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Bicyclo[3.3.1]nonanes as synthetic intermediates. Part 21. Enantiodivergent synthesis of the cis,cis 2,6-disubstituted piperidin-3-ol chiral building block for alkaloid synthesis

Enantiodivergent synthesis of the enantio-pure cis,cis 3-protected 2,6-disubstituted piperidin-3-ol 1 has been achieved via a biochemical method, and the absolute stereochemistry of (+)-1 has been established by its conversion into the known piperidine (-

Asymmetric twin-ring differentiation by lipase-catalyzed enantiotoposelective reaction of the ring-crossed meso glycol: Asymmetric synthesis of a highly functionalized piperidine from the conjoined twin piperidine system

Both enantiomers of the homochiral 3-oxygenated 2,6-cis-disubstituted piperidine 1 were synyhesized by starting with lipase-catalyzed transesterification or hydrolysis of the meso glycol or its diacetate in the conjoined twin piperidine system.