3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile

Base Information

Chemical Name:3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile
CAS No.:888328-95-8
Molecular Formula:C₄₂H₄₆N₂O
Molecular Weight:594.84
Hs Code.:

Synonyms:3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile

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Chemical Property of 3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile

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Technology Process of 3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile

There total 11 articles about 3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-Methoxy-6-methyl-1-[2-methyl-prop-(E)-ylidene]-indan

: 888328-95-8
3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: 0.36 g / hydrogen / Pd/C / 10 h / 760 Torr

2.1: 90 percent / acetic acid; NBS / 2 h / 85 °C

3.1: n-BuLi / tetrahydrofuran / 0.5 h / -75 °C

3.2: tetrahydrofuran / 24 h / 20 °C

3.3: NaOH / H₂O / 1 h

4.1: 0.30 g / Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide; H₂O / 2 h / 120 °C

5.1: BBr₃ / CH₂Cl₂ / 4 h / 15 °C

6.1: 0.21 g / triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

7.1: 71 percent / CuBr; anhydrous LiCl; 2,6-di-tert-butyl-4-methylphenol / PdCl₂(PPh₃)2 / dimethylformamide / 3 h / 160 °C

8.1: BBr₃ / CH₂Cl₂ / 4 h / 15 °C

9.1: 120 mg / K₂CO₃ / dimethylformamide / 2 h / 65 °C

With N-Bromosuccinimide; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; acetic acid; triethylamine; lithium chloride; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/ol052956q

Reference yield:

: 888328-89-0
1-isobutyl-7-methoxy-6-methyl-indan

: 888328-95-8
3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: 90 percent / acetic acid; NBS / 2 h / 85 °C

2.1: n-BuLi / tetrahydrofuran / 0.5 h / -75 °C

2.2: tetrahydrofuran / 24 h / 20 °C

2.3: NaOH / H₂O / 1 h

3.1: 0.30 g / Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide; H₂O / 2 h / 120 °C

4.1: BBr₃ / CH₂Cl₂ / 4 h / 15 °C

5.1: 0.21 g / triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

6.1: 71 percent / CuBr; anhydrous LiCl; 2,6-di-tert-butyl-4-methylphenol / PdCl₂(PPh₃)2 / dimethylformamide / 3 h / 160 °C

7.1: BBr₃ / CH₂Cl₂ / 4 h / 15 °C

8.1: 120 mg / K₂CO₃ / dimethylformamide / 2 h / 65 °C

With N-Bromosuccinimide; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol; boron tribromide; potassium carbonate; caesium carbonate; acetic acid; triethylamine; lithium chloride; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/ol052956q

Reference yield:

: 1-isobutyl-7-methoxy-6-methyl-indan-1-ol

: 888328-95-8
3-{4-[7-(3-benzyl-4-cyanomethoxy-phenyl)-1-isobutyl-6-methyl-indan-4-yl]-3-isobutyl-phenyl}-propionitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: HCl / methanol / 4 h / Heating

2.1: 0.36 g / hydrogen / Pd/C / 10 h / 760 Torr

3.1: 90 percent / acetic acid; NBS / 2 h / 85 °C

4.1: n-BuLi / tetrahydrofuran / 0.5 h / -75 °C

4.2: tetrahydrofuran / 24 h / 20 °C

4.3: NaOH / H₂O / 1 h

5.1: 0.30 g / Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide; H₂O / 2 h / 120 °C

6.1: BBr₃ / CH₂Cl₂ / 4 h / 15 °C

7.1: 0.21 g / triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

8.1: 71 percent / CuBr; anhydrous LiCl; 2,6-di-tert-butyl-4-methylphenol / PdCl₂(PPh₃)2 / dimethylformamide / 3 h / 160 °C

9.1: BBr₃ / CH₂Cl₂ / 4 h / 15 °C

10.1: 120 mg / K₂CO₃ / dimethylformamide / 2 h / 65 °C

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; acetic acid; triethylamine; lithium chloride; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Suzuki coupling;
DOI:10.1021/ol052956q