2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester
CAS No.:404909-83-7
Molecular Formula:C₃₄H₄₉N₅O₈S
Molecular Weight:687.858
Hs Code.:

2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

Synonyms:2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

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Chemical Property of 2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

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Technology Process of 2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

There total 7 articles about 2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-thiazole-4-carboxylic acid ethyl ester; hydrochloride

: 404909-83-7
2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 720 mg / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / morpholine / CH₂Cl₂ / 20 °C

3: 83 percent / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

With morpholine; 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1021/ja017160a

Reference yield:

: 35150-07-3
(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

: 404909-83-7
2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 99 percent / Lawesson's reagent / tetrahydrofuran / 3.5 h / 20 °C

2.1: KHCO₃ / 1,2-dimethoxy-ethane / 0.5 h / 20 °C

2.2: 76 percent / trifluoroacetic anhydride; 2,6-lutidine / 0.5 h / 0 °C

3.1: HCl / dioxane; CH₂Cl₂ / 2 h / 20 °C

4.1: 647 mg / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

5.1: HCl / dioxane; CH₂Cl₂ / 2 h / 20 °C

6.1: 720 mg / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

7.1: 100 percent / morpholine / CH₂Cl₂ / 20 °C

8.1: 83 percent / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

With Lawessons reagent; morpholine; 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ja017160a

Reference yield:

: 117175-41-4,101410-18-8
tert‐butyl (S)‐2‐carbamothioylpyrrolidine‐1‐carboxylate

: 404909-83-7
2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: KHCO₃ / 1,2-dimethoxy-ethane / 0.5 h / 20 °C

1.2: 76 percent / trifluoroacetic anhydride; 2,6-lutidine / 0.5 h / 0 °C

2.1: HCl / dioxane; CH₂Cl₂ / 2 h / 20 °C

3.1: 647 mg / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

4.1: HCl / dioxane; CH₂Cl₂ / 2 h / 20 °C

5.1: 720 mg / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

6.1: 100 percent / morpholine / CH₂Cl₂ / 20 °C

7.1: 83 percent / EDC; HOBT; N-methyl morpholine / CH₂Cl₂ / 0 - 20 °C

With morpholine; 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ja017160a