2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid

Base Information

Chemical Name:2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid
CAS No.:1419169-90-6
Molecular Formula:C₃₂H₂₆O₈S₄
Molecular Weight:666.818
Hs Code.:

Synonyms:2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid

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Chemical Property of 2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid

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Technology Process of 2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid

There total 6 articles about 2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1419172-02-3
C₃₄H₃₀O₈S₄

: 1419169-90-6
2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 58414-52-1
thiophen-3-yl-acetic acid methyl ester

: 1419169-90-6
2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 72 h / 0 - 20 °C

2: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol / 1 h / 60 °C / Inert atmosphere

3: N-Bromosuccinimide; acetic acid / chloroform / 16 h / 0 - 20 °C

4: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol; N,N-dimethyl-formamide / 0.75 h / 65 °C / Inert atmosphere

5: sodium hydroxide / 1,4-dioxane / 18 h / 20 °C

With N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling / 4: |Suzuki Coupling;

Reference yield:

: 1419171-72-4
methyl 2-(2-{4-[3-(2-methoxy-2-oxoethyl)thiophen-2-yl]phenyl}thiophen-3-yl)acetate

: 1419169-90-6
2-(2-{4-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 16 h / 0 - 20 °C

2: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol; N,N-dimethyl-formamide / 0.75 h / 65 °C / Inert atmosphere

3: sodium hydroxide / 1,4-dioxane / 18 h / 20 °C

With N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;