4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid

Base Information

Chemical Name:4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid
CAS No.:1070973-20-4
Molecular Formula:C₂₈H₂₅ClF₃N₃O₅S
Molecular Weight:608.038
Hs Code.:

Synonyms:4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid

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Chemical Property of 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid

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Technology Process of 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid

There total 15 articles about 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070973-14-6
5-[2-chloro-5-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-4-(4-hydroxy-butoxy)-phenyl]-2-trifluoromethyl-isonicotinonitrile

: 1070973-20-4
4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid

Guidance literature:: With sodium periodate; ruthenium trichloride; In dichloromethane; water; acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

: 20364-31-2
4,4-dimethyl-1,2,3,4-tetrahydroquinoline

: 1070973-20-4
4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / water; acetonitrile / 3 h

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 15 h / 90 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C

5.1: sodium periodate / ruthenium trichloride / dichloromethane; water; acetonitrile / 0.5 h / 20 °C

With sodium periodate; potassium acetate; sodium hydride; sodium hydrogencarbonate; sodium carbonate; ruthenium trichloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 76693-04-4
4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one

: 1070973-20-4
4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C

1.2: 0.17 h / 20 °C

2.1: sodium hydrogencarbonate / water; acetonitrile / 3 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 1 h / 0 - 20 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 15 h / 90 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C

6.1: sodium periodate / ruthenium trichloride / dichloromethane; water; acetonitrile / 0.5 h / 20 °C

With sodium periodate; lithium aluminium tetrahydride; potassium acetate; sodium hydride; sodium hydrogencarbonate; sodium carbonate; ruthenium trichloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;