1-(3-phenoxypropyl)azepane hydrochloride

Base Information

• Chemical Name: 1-(3-phenoxypropyl)azepane hydrochloride
• CAS No.: 1402604-28-7
• Molecular Formula: C₁₅H₂₃NO*ClH
• Molecular Weight: 269.815
• Mol file: 1402604-28-7.mol

Synonyms:1-(3-phenoxypropyl)azepane hydrochloride

Chemical Property of 1-(3-phenoxypropyl)azepane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-phenoxypropyl)azepane hydrochloride

There total 1 articles about 1-(3-phenoxypropyl)azepane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

hexamethylene imine (111-49-9) + 3-phenoxypropyl bromide (588-63-6) → 1-(3-phenoxypropyl)azepane hydrochloride (1402604-28-7)

Guidance literature:

hexamethylene imine; 3-phenoxypropyl bromide; With potassium carbonate; In methanol; tert-butyl methyl ether; water; for 18h; Inert atmosphere; Reflux;

With succinic acid anhydride; In methanol; tert-butyl methyl ether; water; at 40 ℃; for 0.5h;

With hydrogenchloride; In tert-butyl methyl ether; isopropyl alcohol; for 0.666667h; Reagent/catalyst;

DOI:10.1021/op300257z

Reference yield:

1-(3-phenoxypropyl)azepane hydrochloride (1402604-28-7) + 4-Chlorobutanoyl chloride (4635-59-0) → 1-(3-(4-(4-chlorobutyl)phenoxy)propyl)azepane hydrochloride (1402604-31-2)

Guidance literature:

1-(3-phenoxypropyl)azepane hydrochloride; 4-Chlorobutanoyl chloride; With aluminum (III) chloride; In methanol; dichloromethane; water; at 5 ℃; Inert atmosphere; Industrial scale;

With triethylsilane; In methanol; dichloromethane; water; at 5 ℃; Inert atmosphere; Industrial scale;

With hydrogenchloride; In methanol; dichloromethane; water; at 10 ℃; for 0.166667h; Inert atmosphere; Industrial scale;

DOI:10.1021/op300257z

Reference yield:

1-(3-phenoxypropyl)azepane hydrochloride (1402604-28-7) + 4-Chlorobutanoyl chloride (4635-59-0) → 1-(4-(3-(azepan-1-yl)propoxy)phenyl)-4-chlorobutan-1-one hydrochloride (1402604-29-8)

Guidance literature:

1-(3-phenoxypropyl)azepane hydrochloride; 4-Chlorobutanoyl chloride; With aluminum (III) chloride; In methanol; dichloromethane; water; at 5 ℃; Inert atmosphere;

With hydrogenchloride; In methanol; ethanol; dichloromethane; water; at 20 ℃; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1021/op300257z

upstream raw materials:

hexamethylene imine

3-phenoxypropyl bromide

Downstream raw materials:

1-(3-(4-(4-chlorobutyl)phenoxy)propyl)azepane hydrochloride

1-(4-(3-(azepan-1-yl)propoxy)phenyl)-4-chlorobutan-1-one hydrochloride