dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate

Base Information

• Chemical Name: dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate
• CAS No.: 1380436-17-8
• Molecular Formula: C₂₁H₂₆O₅
• Molecular Weight: 358.434
• Mol file: 1380436-17-8.mol

Synonyms:dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate

Chemical Property of dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate

There total 3 articles about dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

sorbyl bromide (63072-78-6,50999-04-7) + dimethyl [(2E)-3-(4-methoxyphenyl)prop-2-en-1-yl]malonate (212777-65-6) → dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate (1380436-17-8)

Guidance literature:

dimethyl [(2E)-3-(4-methoxyphenyl)prop-2-en-1-yl]malonate; With sodium hydride; In tetrahydrofuran; for 0.5h;

sorbyl bromide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2012.04.021

Reference yield:

(E)-4-methoxycinnamyl bromide (90841-43-3,16034-99-4) → dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate (1380436-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h

1.2: 1.5 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h

2.2: 3 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2012.04.021

Reference yield:

malonic acid dimethyl ester (108-59-8) → dimethyl 2-((2E,4E)-hexa-2,4-dien-1-yl)-2-((E)-3-(4-methoxyphenyl)allyl)-malonate (1380436-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h

1.2: 1.5 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h

2.2: 3 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2012.04.021

upstream raw materials:

sorbyl bromide

dimethyl [(2E)-3-(4-methoxyphenyl)prop-2-en-1-yl]malonate

(E)-4-methoxycinnamyl bromide

malonic acid dimethyl ester