tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

Base Information

Chemical Name:tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane
CAS No.:934536-76-2
Molecular Formula:C₂₁H₃₁IOSi
Molecular Weight:454.467
Hs Code.:

<i>tert</i>-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

Synonyms:tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

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Chemical Property of tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

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Technology Process of tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

There total 6 articles about tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 934536-68-2
1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-6-yn-1-one

: 69739-34-0
t-butyldimethylsiyl triflate

: tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

: 934536-76-2
tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ja068723r

Reference yield:

: 934536-73-9
3-(2-iodo-5-methyl-phenyl)-3-oxo-propionic acid ethyl ester

: 934536-76-2
tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.5 h

1.2: 51 percent / tetrahydrofuran; dimethylformamide / 20 h / 80 °C

2.1: 80 percent / NaH / dimethylformamide / 1 h / 0 °C

3.1: 42 percent / aq. NaOH / ethanol / 48 h / 20 °C

4.1: 72 percent / triethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja068723r

Reference yield:

: 934536-74-0
2-(2-iodo-5-methyl-benzoyl)-hept-6-ynoic acid ethyl ester

: 934536-76-2
tert-butyl-[1-(2-iodo-5-methyl-phenyl)-2-methyl-hept-1-en-6-ynyloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / NaH / dimethylformamide / 1 h / 0 °C

2: 42 percent / aq. NaOH / ethanol / 48 h / 20 °C

3: 72 percent / triethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; sodium hydride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja068723r