((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester
CAS No.:1477815-14-7
Molecular Formula:C₂₇H₃₀F₃N₅O₄
Molecular Weight:545.562
Hs Code.:

Synonyms:((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

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Chemical Property of ((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

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Technology Process of ((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

There total 6 articles about ((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116369-25-6
4-bromo-3-(trifluoromethoxy)phenylamine

: 1228553-33-0
[(S)-2-methyl-1-((S)-2-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)propyl]carbamic acid methyl ester

: 76-05-1
trifluoroacetic acid

: 1477815-14-7
((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

: ((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester di(trifluoroacetate)

Guidance literature:: 4-bromo-3-(trifluoromethoxy)phenylamine; [(S)-2-methyl-1-((S)-2-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)propyl]carbamic acid methyl ester; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 100 ℃; Inert atmosphere; Sealed tube;

trifluoroacetic acid; With acetic acid; In water; toluene; Overall yield = 80 %; Inert atmosphere; Sealed tube;

Reference yield:

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1477815-14-7
((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 85 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 100 °C / Inert atmosphere; Sealed tube

3.2: Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1228552-27-9
((S)-1-{(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

: 1477815-14-7
((S)-1-{(S)-2-[4-(4'-amino-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 85 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 100 °C / Inert atmosphere; Sealed tube

2.2: Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In 1,4-dioxane; water; toluene;