2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide
CAS No.:1198297-75-4
Molecular Formula:C₁₄H₁₅ClF₃N₃O₃S
Molecular Weight:397.806
Hs Code.:

Synonyms:2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide

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Chemical Property of 2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide

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Technology Process of 2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide

There total 4 articles about 2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₃ClF₃N₃O₅S

: 1198297-75-4
2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide

Guidance literature:: C₁₉H₂₃ClF₃N₃O₅S; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonia; In methanol;

Reference yield:

: 774610-01-4
1,1-dimethylethyl(1S,4S)-5-(N-{[benzyloxy]carbonyl}glycyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: 1198297-75-4
2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h

With ammonium formate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 1198297-75-4
2-chloro-N-{2-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-oxoethyl}-5-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

3: triethylamine / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h

With 4-methyl-morpholine; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;