methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate

Base Information

• Chemical Name: methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate
• CAS No.: 1407834-04-1
• Molecular Formula: C₁₁H₁₃FN₂O₄
• Molecular Weight: 256.234
• Mol file: 1407834-04-1.mol

Synonyms:methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate

Chemical Property of methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate

There total 3 articles about methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

β-amino-α-methyl propionic acid methyl ester (14678-48-9) + 1,4-difluoro-2-nitrobenzene (364-74-9) → methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate (1407834-04-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 15h; Reflux;

Reference yield:

methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate (1407834-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 12 h / 20 °C

2: hydrogen / palladium(II) hydroxide / methanol / 12 h / 20 °C

3: potassium carbonate / tetrahydrofuran / 15 h / Reflux

With hydrogen; potassium carbonate; palladium(II) hydroxide; In tetrahydrofuran; methanol;

Reference yield:

methyl 3-(benzylamino)-2-methylpropanoate (4010-62-2) → methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate (1407834-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium(II) hydroxide / methanol / 12 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 15 h / Reflux

With hydrogen; potassium carbonate; palladium(II) hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

β-amino-α-methyl propionic acid methyl ester

1,4-difluoro-2-nitrobenzene

methacrylic acid methyl ester

methyl 3-(benzylamino)-2-methylpropanoate

Downstream raw materials:

4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-9-fluoro-6-(4-chloro-phenyl)

methyl 3-(2-amino-4-fluorophenylamino)-2-methylpropanoate