14678-48-9

Basic information

• Product Name: Methyl 3-amino-2-methylpropanoate
• Synonyms: Methyl 3-amino-2-methylpropanoate
• CAS NO: 14678-48-9
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• Mol File: 14678-48-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 159.8±23.0 °C(Predicted)
• Appearance: /
• Density: 0.987±0.06 g/cm3(Predicted)
• PKA: 8.69±0.10(Predicted)
• CAS DataBase Reference: Methyl 3-amino-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-amino-2-methylpropanoate(14678-48-9)
• EPA Substance Registry System: Methyl 3-amino-2-methylpropanoate(14678-48-9)

Safety Data

• Hazardous Substances Data: 14678-48-9(Hazardous Substances Data)

Usage

General Description

Methyl 3-amino-2-methylpropanoate is a chemical compound with the molecular formula C5H11NO2. It is an amino acid derivative that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. It is also used in organic synthesis as a chiral auxiliary and as a reagent for the preparation of various heterocyclic compounds. Methyl 3-amino-2-methylpropanoate is a white to off-white crystalline solid that is soluble in polar organic solvents such as methanol and ethanol. It is important to handle and store this compound in a well-ventilated area, away from heat and ignition sources, as it may pose a fire hazard.

Upstream product

• 56133-37-0 methyl 1,2-thiazole-4-carboxylate 
• 67-56-1 methanol 
• 10569-72-9 DL-3-aminoisobutyric acid 
• 80-62-6 methacrylic acid methyl ester 
• 390410-26-1 methyl 2-[(dibenzylamino)methyl]propionate 
• 94143-85-8 3-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-2-methyl-propionic acid methyl ester 
• 4010-62-2 methyl 3-(benzylamino)-2-methylpropanoate 

Downstream Products

• 52223-66-2 3-{3-[1-Dimethylamino-eth-(E)-ylideneamino]-2,4,6-triiodo-5-methylcarbamoyl-benzoylamino}-2-methyl-propionic acid 
• 10569-72-9 DL-3-aminoisobutyric acid 
• 1312927-86-8 C₂₄H₃₀N₂O₆ 
• 1312928-08-7 C₁₆H₂₄N₂O₄ 
• 1312928-09-8 C₃₂H₅₄N₂O₅ 
• 1407834-04-1 methyl 3-(4-fluoro-2-nitrophenylamino)-2-methylpropanoate 
• 1407833-48-0 methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate 
• 1407834-07-4 methyl 3-(2-amino-4-fluorophenylamino)-2-methylpropanoate 
• 1407833-52-6 methyl 3-(2-amino-5-bromophenylamino)-2-methylpropanoate 
• 90043-93-9 N-(5,5-dimethyl-3-oxocyclohex-1-enyl)-2-methyl-β-alanine methyl ester 

Relevant articles and documents

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Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains

Inhibition of the bromodomains of the BET family, of which BRD4 is a member, has been shown to decrease myc and interleukin (IL) 6 in vivo, markers that are of therapeutic relevance to cancer and inflammatory disease, respectively. Herein we report substituted benzo[b]isoxazolo[4,5-d]azepines and benzotriazolo[4,3-d][1,4]diazepines as fragment-derived novel inhibitors of the bromodomain of BRD4. Compounds from these series were potent and selective in cells, and subsequent optimization of microsomal stability yielded representatives that demonstrated dose- and time-dependent reduction of plasma IL-6 in mice.

MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF

Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.