Technology Process of (5aS,11aR)-5-benzyl-10-methyl-10,11-dihydro-5H-5a,11a-butanocyclopenta[1,2-b:3,4-b']diindole
There total 4 articles about (5aS,11aR)-5-benzyl-10-methyl-10,11-dihydro-5H-5a,11a-butanocyclopenta[1,2-b:3,4-b']diindole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin;
In
toluene;
at 45 ℃;
for 24h;
enantioselective reaction;
DOI:10.1002/anie.201301618
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide
2: hydrogen; palladium 10% on activated carbon
3: (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin / toluene / 24 h / 45 °C
With
palladium 10% on activated carbon; (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin; hydrogen; sodium hydroxide;
In
toluene;
3: |Fischer Indole Synthesis;
DOI:10.1002/anie.201301618
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide
2: hydrogen; palladium 10% on activated carbon
3: (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin / toluene / 24 h / 45 °C
With
palladium 10% on activated carbon; (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin; hydrogen; sodium hydroxide;
In
toluene;
3: |Fischer Indole Synthesis;
DOI:10.1002/anie.201301618
