4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile

Base Information

Chemical Name:4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile
CAS No.:1600565-75-0
Molecular Formula:C₂₇H₁₈Cl₂N₄O
Molecular Weight:485.372
Hs Code.:

Synonyms:4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile

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Chemical Property of 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile

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Technology Process of 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile

There total 12 articles about 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600565-48-7
(4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol

: 76-05-1
trifluoroacetic acid

: 1600565-75-0
4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile

Guidance literature:: zinc(II) cyanide; (4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol; With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 120 ℃; for 4h; Sealed tube; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile; Sealed tube; Inert atmosphere;

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600565-48-7
(4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol

: 1600565-75-0
4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 120 ℃; for 4h; Reflux;
DOI:10.1016/j.bmcl.2017.02.044

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600565-75-0
4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: n-butyllithium / tetrahydrofuran / 1.67 h / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 4 h / 120 °C / Sealed tube; Inert atmosphere

4.2: Sealed tube; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; lithium hexamethyldisilazane; zinc; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water;