[9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide

Base Information

• Chemical Name: [9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide
• CAS No.: 884845-79-8
• Molecular Formula: C₂₀H₂₇NO₂
• Molecular Weight: 314.429

Synonyms:[9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide

Chemical Property of [9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of [9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide

There total 4 articles about [9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

[9-13C]-N-benzyl-N-methoxyacrylamide (884845-77-6) + 2,6,6-trimethylcyclohex-1-en-1-yl trifluoromethanesulfonate (99747-72-5) → [9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide (884845-79-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 75 ℃;

DOI:10.1021/ja0581604

Reference yield:

[9-13C]-N-benzyl-2-bromo-N-methoxyacetamide (884845-73-2) → [9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide (884845-79-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 180 °C

2: 65 percent / K₂CO₃ / H₂O / 40 °C

3: 79 percent / Pd(PPh₃)2Cl₂; Et₃N / dimethylformamide / 75 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.1021/ja0581604

Reference yield:

[9-13C]-diethyl (N-benzyl-N-methoxycarbamoyl)-methylphosphonate (884845-75-4) → [9-13C]-(2E)-N-benzyl-N-methoxy-3-(2,6,6-trimethylcyclohex)-1-enyl acrylamide (884845-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / K₂CO₃ / H₂O / 40 °C

2: 79 percent / Pd(PPh₃)2Cl₂; Et₃N / dimethylformamide / 75 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.1021/ja0581604

upstream raw materials:

[9-13C]-N-benzyl-N-methoxyacrylamide

2,6,6-trimethylcyclohex-1-en-1-yl trifluoromethanesulfonate

[9-13C]-N-benzyl-2-bromo-N-methoxyacetamide

[9-13C]-diethyl (N-benzyl-N-methoxycarbamoyl)-methylphosphonate

Downstream raw materials:

[9,10-13C₂]-(2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethyl cyclohex-1-enyl)penta-2,4-dienoate

[9,10-13C₂]-1,3,3-trimethyl-2-((1E,3E)-3-methylhexa-1,3-dien-5-ynyl)cyclohex-1-ene

[9,10-13C₂]-(2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienal

[9-13C]-β-ionone

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