99747-72-5

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 2,6,6-trimethyl-1-cyclohexen-1-yl ester
• CAS NO: 99747-72-5
• Molecular Formula: C10H15F3O3S
• Molecular Weight: 272.289
• Mol File: 99747-72-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 2,6,6-trimethyl-1-cyclohexen-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 2,6,6-trimethyl-1-cyclohexen-1-yl ester(99747-72-5)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 2,6,6-trimethyl-1-cyclohexen-1-yl ester(99747-72-5)

Safety Data

• Hazardous Substances Data: 99747-72-5(Hazardous Substances Data)

Upstream product

• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 

Downstream Products

• 137273-42-8 1-<4-(Trifluoromethyl)phenyl>-2,6,6-trimethylcyclohex-1-ene 
• 5293-90-3 1,3,3-trimethyl-2-vinylcyclohexene 
• 144994-01-4 ethyl 9-desmethylretinoate 
• 60347-68-4 ethyl all-E-13-demethylretinoate 
• 3899-20-5 ethyl (all-E)-retinoate 
• 86708-67-0 ethyl (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate 
• 3917-39-3 (2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexenyl)-2,4-pentadien-1-ol 
• 1415982-08-9 ethyl 9-(2,6,6-trimethylcyclohex-1-en-1-yl)nonanoate 
• 1415982-09-0 9-(2,6,6-trimethylcyclohex-1-en-1-yl)nonanoic acid 
• 302-79-4 9-cis-retinoic acid 

Relevant articles and documents

Relay-Heck Cross-Coupling Between Alkenyl Halides and Unsaturated Alcohols in the Synthesis of Open-Chain Analogues of Musk Odorant Vulcanolide

Unactivated alkenyl iodides and bromides underwent an unprecedented palladium-catalyzed relay-Heck cross-coupling with a whole range of alkenols of different chain lengths linking the alkene and the alcohol, affording unsaturated aldehydes and ketones in moderate to good yields. In contrast, alkenyl triflates were not suitable partners for this reaction. This method allowed the preparation of open-chain analogues of the musk odorant Vulcanolide, several of which retained key olfactory properties of the parent molecule.

COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING SIRNA ACTIVITY

Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of -CH2-, -S-, and -O- or absent; wherein Y is selected from -(CH2)n, -S(CH2)n, -O(CH2)n-, thiophene, -SO2(CH2)n-, and ester, wherein n = 1 -4; wherein a = 1 -4; wherein b=l -4; wherein c=l-4; and wherein Z is a counterion; and compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including one or both of these compounds which are useful for the delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.

INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS

The present invention relates to compounds defined by formula (I) wherein the variables R1, R2, R3, m, and n are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are activators of the receptor GPR40 and thus are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.