methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate

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Chemical Name:methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate
CAS No.:1613056-68-0
Molecular Formula:C₂₃H₂₃BrN₄O₃
Molecular Weight:483.365
Hs Code.:

Synonyms:methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate

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Chemical Property of methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate

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Technology Process of methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate

There total 4 articles about methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole dihydrochloride

: 60725-19-1
(S)-2-((methoxycarbonyl)amino)-2-phenylacetic acid

: 1613056-68-0
methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1613056-68-0
methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Sealed tube

2: ammonium acetate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / ethyl acetate / 8 h / 20 °C / Inert atmosphere; Sealed tube

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; ammonium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; toluene;

Reference yield:

: 128120-93-4
(S)-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromophenyl)-2-oxoethyl]ester 1-tert-butyl ester

: 1613056-68-0
methyl ((S)-2-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / ethyl acetate / 8 h / 20 °C / Inert atmosphere; Sealed tube

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; ammonium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; toluene;