tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate
CAS No.:210880-82-3
Molecular Formula:C₂₁H₂₅Br₃N₂O₄
Molecular Weight:609.153
Hs Code.:

Synonyms:tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

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Chemical Property of tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

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Technology Process of tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

There total 4 articles about tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 210880-89-0
tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

: 210880-82-3
tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Guidance literature:: With chromium dichloride; In methanol; dichloromethane; at 24 ℃; for 0.5h;
DOI:10.1021/jo9721204

Reference yield:

: 210880-88-9
N-(tert-butoxycarbonyl)-3,5-dibromo-4-hydroxy-β-phenethylamine

: 210880-82-3
tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / cerium(IV) diammonium nitrate / acetonitrile; H₂O / 1 h / 0 °C

2: 0.59 g / Na₂S₂O₄ / H₂O; tetrahydrofuran / 0.17 h / 20 °C

With sodium dithionite; ammonium cerium(IV) nitrate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.tet.2005.05.038

Reference yield:

: 51-67-2
tyrosamine

: 210880-82-3
tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: Br₂; AcOH / 50 °C

2: 24 g / Et₃N / methanol / 2 h / 20 °C

3: 53 percent / cerium(IV) diammonium nitrate / acetonitrile; H₂O / 1 h / 0 °C

4: 0.59 g / Na₂S₂O₄ / H₂O; tetrahydrofuran / 0.17 h / 20 °C

With sodium dithionite; ammonium cerium(IV) nitrate; bromine; acetic acid; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1016/j.tet.2005.05.038