tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

Base Information

Chemical Name:tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate
CAS No.:210880-89-0
Molecular Formula:C₂₂H₂₃Br₃N₂O₆
Molecular Weight:651.146
Hs Code.:

Synonyms:tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

There total 3 articles about tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 210880-88-9
N-(tert-butoxycarbonyl)-3,5-dibromo-4-hydroxy-β-phenethylamine

: 210880-89-0
tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

Guidance literature:: With dihydrogen peroxide; soybean peroxidase; In acetonitrile; at 24 ℃; for 0.333333h; pH 5.0;
DOI:10.1021/jo9721204

Reference yield:

: 51-67-2
tyrosamine

: 210880-89-0
tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂; AcOH / 50 °C

2: 24 g / Et₃N / methanol / 2 h / 20 °C

3: 53 percent / cerium(IV) diammonium nitrate / acetonitrile; H₂O / 1 h / 0 °C

With ammonium cerium(IV) nitrate; bromine; acetic acid; triethylamine; In methanol; water; acetonitrile;
DOI:10.1016/j.tet.2005.05.038

Reference yield:

: 73414-58-1
2-(3,5-dibromo-4-hydroxyphenyl)ethan-1-amine hydrobromide

: 210880-89-0
tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 24 g / Et₃N / methanol / 2 h / 20 °C

2: 53 percent / cerium(IV) diammonium nitrate / acetonitrile; H₂O / 1 h / 0 °C

With ammonium cerium(IV) nitrate; triethylamine; In methanol; water; acetonitrile;
DOI:10.1016/j.tet.2005.05.038