Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester

Base Information

Chemical Name:Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester
CAS No.:220166-67-6
Molecular Formula:C₁₆H₂₆FO₈PS
Molecular Weight:428.416
Hs Code.:

Synonyms:Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester

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Chemical Property of Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester

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Technology Process of Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester

There total 4 articles about Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 124-63-0
methanesulfonyl chloride

: 220166-37-0
[(2-Benzyloxy-1-hydroxymethyl-ethoxy)-fluoro-methyl]-phosphonic acid diethyl ester

: 220166-67-6
Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester

Guidance literature:: With triethylamine; In dichloromethane; 1.) 0 deg C, 1 h, 2.) r.t., overnight;
DOI:10.1039/a805929b

Reference yield:

: (2-Benzyloxy-1-hydroxymethyl-ethoxymethyl)-phosphonic acid diethyl ester

: 220166-67-6
Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

2: 1.) n-BuLi, 2.) (PhSO₂)2NF / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, -78 deg C, 2.5 h; -78 deg C to -10 deg C

3: 76 percent / Dowex 50WX₈ / ethanol / Ambient temperature

4: 94 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

With dmap; n-butyllithium; Dowex 50WX8 ; N-fluorobis(benzenesulfon)imide; triethylamine; In ethanol; dichloromethane;
DOI:10.1039/a805929b

Reference yield:

: 220166-30-3
{[1-Benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-fluoro-methyl}-phosphonic acid diethyl ester

: 220166-67-6
Methanesulfonic acid 3-benzyloxy-2-[(diethoxy-phosphoryl)-fluoro-methoxy]-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / Dowex 50WX₈ / ethanol / Ambient temperature

2: 94 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

With Dowex 50WX8 ; triethylamine; In ethanol; dichloromethane;
DOI:10.1039/a805929b