2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

Base Information

Chemical Name:2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate
CAS No.:1357158-13-4
Molecular Formula:C₁₉H₂₈BrN₃O₄S
Molecular Weight:474.419
Hs Code.:

Synonyms:2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

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Chemical Property of 2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

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Technology Process of 2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

There total 8 articles about 2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1357158-08-7
2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol

: 124-63-0
methanesulfonyl chloride

: 1357158-13-4
2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Cooling;
DOI:10.1002/cjoc.201180354

Reference yield:

: 948292-48-6,1048930-76-2
3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester

: 1357158-13-4
2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 3.17 h / 20 °C / Reflux

2.1: potassium carbonate; potassium iodide / acetonitrile / 5.17 h / 20 °C / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

4.1: potassium / Inert atmosphere

4.2: 0.17 h / Inert atmosphere

4.3: 3 h / Inert atmosphere; Reflux

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling

With lithium aluminium tetrahydride; potassium; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/cjoc.201180354

Reference yield:

: 1357157-92-6
(3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methanol

: 1357158-13-4
2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium / Inert atmosphere

1.2: 0.17 h / Inert atmosphere

1.3: 3 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling

With lithium aluminium tetrahydride; potassium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/cjoc.201180354