tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate

Base Information

Chemical Name:tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate
CAS No.:869366-53-0
Molecular Formula:C₂₁H₁₉ClFNO₃
Molecular Weight:387.838
Hs Code.:

Synonyms:tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate

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Technology Process of tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate

There total 3 articles about tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 92136-39-5
N-tert-Butoxycarbonyl-1-amino-3-propyne

: 76049-49-5
(5-chloro-2-iodophenyl)(2-fluorophenyl)methanone

: 869366-53-0
tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ml500409n

Reference yield:

: 784-38-3
2-amino-5-chloro-2'-fluorobenzophenone

: 869366-53-0
tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; hydrogenchloride; sodium nitrite; potassium iodide / water; ethyl acetate / 10 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; acetic acid; triethylamine; potassium iodide; sodium nitrite; In dichloromethane; water; ethyl acetate; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/ml500409n