76049-49-5

Upstream product

• 4743-17-3 5-Chloroisatoic anhydride 
• 1072-85-1 o-fluorobromobenzene 
• 150879-48-4 N-methyl-N-methyloxy-2-amino-5-chlorobenzamide 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 

Downstream Products

• 76049-58-6 <5-chloro-2-(3-hydroxy-1-propynyl)phenyl>(2-fluorophenyl)methanone 
• 58582-30-2 8-Chloro-4-[1-dimethylamino-meth-(E)-ylidene]-1-(2-fluoro-phenyl)-3,4-dihydro-benzo[c]azepin-5-one 
• 869366-53-0 tert-butyl {3-[4-chloro-2-(2-fluorobenzoyl)phenyl]prop-2-yn-1-yl}carbamate 
• 76049-63-3 3-Amino-1-[4-chloro-2-(2-fluorobenzoyl)phenyl]propyne 
• 58583-07-6 8-chloro-1-(2-fluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one 
• 76049-53-1 1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-phthalimidopropyne 

Relevant academic research and scientific papers

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates are described. Strong Br?nsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alcohol derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and density functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge.

Cu(I)-Catalyzed Coupling and Cycloisomerization of Diazo Compounds with Terminal Yne-Alkylidenecyclopropanes: Synthesis of Functionalized Cyclopenta[ b]naphthalene Derivatives

A Cu(I)-catalyzed coupling and cycloisomerization of diazo compounds with terminal yne-alkylidenecyclopropanes (ACPs) has been presented. This reaction starts from the formation of an allenic intermediate in the Cu(I)-catalyzed cross-coupling reaction of a diazo compound with terminal alkyne in yne-tethered ACP and then undergoes a domino cycloisomerization of a 6π-electrocyclization and cyclopropane ring-opening rearrangement to give functionalized cyclopenta[b]naphthalene derivatives in moderate to excellent yields under mild conditions.

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat

3H-2-Benzazepines

There is presented 3H-2-benzazepines and 4,5-dihydro-3H-2-benzazepines of the formula STR1 wherein X is hydrogen, chloro or bromo, Y is hydrogen, fluoro or chloro with the proviso that X and Y cannot both be hydrogen and R1 is selected from the

Pyrimido[4,5-d][2]benzazepines

There is presented a compound of the formula STR1 wherein R1 is selected from the group consisting of hydrogen, lower alkyl, chloro, bromo, alkoxy, hydroxy, lower alkyl substituted thio and NR4 R5 wherein R4 and

N-oxides of 5-oxo-1-phenyl-2-benzazepines

Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ

2-Benzazepines. 1. Synthesis of 2-Benzazepin-4-ones and -5-ones via 2-Acetylenic Benzophenones

The preparation of 1-phenyl-2-benzazepin-4-ones and -5-ones is discussed.The palladium-catalyzed coupling of an iodobenzophenone to a monosubstituted acetylene assembles the necessary atoms required for the benzazepine ring.Transformation of the acetylene

Intermediates in the production of 2-benzazepines

Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ

Triazolobenzazepines and processes for their production

There is presented triazolobenzazepines of the formula STR1 wherein R1 is hydrogen or lower alkyl and X and Y are hydrogen or halogen and the pharmaceutically acceptable salts thereof. Also disclosed are novel processes and intermediates leadin