Technology Process of 1-[(2R,3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2,3-dihydroxy-propyl)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
There total 11 articles about 1-[(2R,3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2,3-dihydroxy-propyl)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 18h;
under 760 Torr;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 72 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
2: 82 percent / Et3N, DMAP, pyridine / CH2Cl2 / 40 h / Ambient temperature
3: 79 percent / AIBN / benzene / 20 h / Heating
4: 90 percent / aq. NaOH / tetrahydrofuran / 5 h / Ambient temperature
5: 92 percent / DBU / acetonitrile / 18 h / Ambient temperature
6: 83 percent / PPh3, diisopropylazodicarboxylate / toluene / 50 h / Ambient temperature
7: 92 percent / NaOMe / methanol / 1 h / Ambient temperature
8: 94 percent / NaH / tetrahydrofuran / 17 h / Ambient temperature
9: 61 percent / OsO4, N-methylmorpholine-N-oxide, H2O / acetone / 18 h / Ambient temperature
10: 83 percent / H2 / 10percent Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
With
pyridine; 1H-imidazole; dmap; sodium hydroxide; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; water; hydrogen; sodium methylate; sodium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 72 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
2: 82 percent / Et3N, DMAP, pyridine / CH2Cl2 / 40 h / Ambient temperature
3: 79 percent / AIBN / benzene / 20 h / Heating
4: 90 percent / aq. NaOH / tetrahydrofuran / 5 h / Ambient temperature
5: 92 percent / DBU / acetonitrile / 18 h / Ambient temperature
6: 83 percent / PPh3, diisopropylazodicarboxylate / toluene / 50 h / Ambient temperature
7: 92 percent / NaOMe / methanol / 1 h / Ambient temperature
8: 94 percent / NaH / tetrahydrofuran / 17 h / Ambient temperature
9: 61 percent / OsO4, N-methylmorpholine-N-oxide, H2O / acetone / 18 h / Ambient temperature
10: 83 percent / H2 / 10percent Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
With
pyridine; 1H-imidazole; dmap; sodium hydroxide; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; water; hydrogen; sodium methylate; sodium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; benzene;
![3-Benzyloxymethyl-1-[(2R,3R,4R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(2,3-dihydroxy-propyl)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione](/Databaselist/images/loading.webp)
