3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide
CAS No.:913067-92-2
Molecular Formula:C₁₂H₁₂ClF₃N₂O₃
Molecular Weight:324.687
Hs Code.:
DSSTox Substance ID:DTXSID401153226

Synonyms:3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide;3-chloro-2,2-dimethyl-N-[2-nitro-4-(trifluoromethyl)phenyl]propanamide;SCHEMBL2746424;DTXSID401153226;AKOS012991630;913067-92-2

Suppliers and Price of 3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:324.0488544
Heavy Atom Count:21
Complexity:410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(CCl)C(=O)NC1=C(C=C(C=C1)C(F)(F)F)[N+](=O)[O-]

Technology Process of 3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide

There total 1 articles about 3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4300-97-4
3-Chloropivaloyl chloride

: 400-98-6
4-trifluoromethyl-2-nitroaniline

: 913067-92-2
3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With triethylamine; In dichloromethane; at 35 ℃; for 24h;
DOI:10.1021/jm0605482

Reference yield:

: 913067-92-2
3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide

: 861881-16-5
3,3-dimethyl-1-(2-nitro-4-trifluoromethyl-phenyl)-azetidin-2-one

Guidance literature:: With potassium carbonate; In acetone; at 50 ℃; for 72h;
DOI:10.1021/jm0605482

Reference yield:

: 913067-92-2
3-chloro-2,2-dimethyl-N-(2-nitro-4-(trifluoromethyl)phenyl)propanamide

: 861881-17-6
1-(2-amino-4-(trifluoromethyl)phenyl)-3,3-dimethylazetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / 72 h / 50 °C

2: 1.75 g / H₂ / Pd/C / methanol; ethyl acetate / 24 h

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; ethyl acetate; acetone;
DOI:10.1021/jm0605482