ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate

Base Information

Chemical Name:ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate
CAS No.:1296212-23-1
Molecular Formula:C₁₈H₂₈ClNO₅Si
Molecular Weight:401.963
Hs Code.:

Synonyms:ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate

Chemical Property:

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Technology Process of ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate

There total 2 articles about ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1296212-22-0
ethyl 4-(5-chloro-2-nitrophenyl)-4-hydroxybutanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1296212-23-1
ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 1296212-23-1
ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: zinc dibromide / dichloromethane / 0 - 20 °C

2: citric acid / ethanol; water / 1.5 h / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; citric acid; zinc dibromide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1296212-23-1
ethyl 4-(tert-butyldimethylsilyloxy)-4-(5-chloro-2-nitrophenyl)butanoate

: 1296212-19-5
N-(4-(7-chloro-5-hydroxy-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 30 °C

1.2: 3 h / 760.05 Torr / Inert atmosphere

1.3: 72 h / 20 °C

2.1: boron trifluoride diethyl etherate; sodium borodeuteride / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 4 h / 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4.2: 0 °C

With sodium borodeuteride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;