5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid

Base Information

Chemical Name:5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid
CAS No.:1235741-69-1
Molecular Formula:C₂₃H₁₈F₂N₄O₄
Molecular Weight:452.417
Hs Code.:

Synonyms:5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid

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Chemical Property of 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid

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Technology Process of 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid

There total 7 articles about 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1235741-67-9
methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

: 1235741-69-1
5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid

Guidance literature:: methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; water; pH=4;

Reference yield:

: 38116-61-9
2-hydroxy-6-methylnicotinic acid

: 1235741-69-1
5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; bromine; water / 0 - 20 °C

1.2: pH 1 - 2

2.1: silver carbonate / chloroform / 96 h / In the dark

3.1: 1,1'-bis-(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

4.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

5.1: sodium hydroxide; water / 1,4-dioxane / 18 h / 20 °C

5.2: pH 4

With 1,1'-bis-(diphenylphosphino)ferrocene; water; bromine; silver carbonate; trifluoroacetic acid; sodium hydroxide; palladium diacetate; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 503437-35-2
5-bromo-2-hydroxy-6-methylnicotinic acid

: 1235741-69-1
5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver carbonate / chloroform / 96 h / In the dark

2.1: 1,1'-bis-(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 18 h / 20 °C

4.2: pH 4

With 1,1'-bis-(diphenylphosphino)ferrocene; water; silver carbonate; trifluoroacetic acid; sodium hydroxide; palladium diacetate; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;