methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

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Chemical Name:methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate
CAS No.:1235741-67-9
Molecular Formula:C₂₄H₂₀F₂N₄O₄
Molecular Weight:466.444
Hs Code.:

Synonyms:methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

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Chemical Property of methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

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Technology Process of methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

There total 6 articles about methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1235741-65-7
methyl 5-(3-(tert-butoxycarbonyl(methyl)carbamoyl)-4-fluoro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

: 1235741-67-9
methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: 38116-61-9
2-hydroxy-6-methylnicotinic acid

: 1235741-67-9
methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; bromine; water / 0 - 20 °C

1.2: pH 1 - 2

2.1: silver carbonate / chloroform / 96 h / In the dark

3.1: 1,1'-bis-(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

4.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; water; bromine; silver carbonate; trifluoroacetic acid; sodium hydroxide; palladium diacetate; In dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 503437-35-2
5-bromo-2-hydroxy-6-methylnicotinic acid

: 1235741-67-9
methyl 5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-2-methoxy-6-methylnicotinate

Guidance literature:: Multi-step reaction with 3 steps

1: silver carbonate / chloroform / 96 h / In the dark

2: 1,1'-bis-(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; silver carbonate; trifluoroacetic acid; palladium diacetate; In dichloromethane; chloroform; N,N-dimethyl-formamide;