1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

Base Information

Chemical Name:1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride
CAS No.:228259-19-6
Molecular Formula:C₁₃H₉ClF₃N₅O₂
Molecular Weight:359.695
Hs Code.:

Synonyms:1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

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Chemical Property of 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

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Technology Process of 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

There total 10 articles about 1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 228259-18-5
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid

: 228259-19-6
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

Guidance literature:: N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 228259-18-5
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid

: 228259-19-6
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-19-6
1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride

Guidance literature:: Multi-step reaction with 7 steps

1: AcOH / 4 h / 100 °C

2: N-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

3: 1.5 g / NaBH₄ / tetrahydrofuran; H₂O

4: Et₃N / CHCl₃ / 4 h / cooling

5: 1.43 g / NaN₃ / dimethylformamide / 2 h / 60 °C

6: 68 percent / potassium permanganate / acetone; H₂O / 3 h / 60 °C

7: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / 0 °C

With 4-methyl-morpholine; sodium tetrahydroborate; potassium permanganate; sodium azide; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm030212h