cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine

Base Information

Chemical Name:cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine
CAS No.:80542-45-6
Molecular Formula:C₂₀H₁₆N₂O₆
Molecular Weight:380.357
Hs Code.:

Synonyms:cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine

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Chemical Property of cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine

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Technology Process of cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine

There total 2 articles about cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 6780-38-7
N-phthaloylglycine chloride

: 124156-20-3,72079-55-1
(4-methoxyphenyl-benzylidene)-carbamic acid methyl ester

: 80542-45-6
cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; 1.) 5 min, 2.) 20 min;
DOI:10.1021/jo00135a016

Reference yield:

: 104-94-9
4-methoxy-aniline

: 80542-45-6
cis-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-4-(methoxycarbonyl)-1-(4-methoxyphenyl)-2-oxazetidine

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / MgSO₄ / CH₂Cl₂ / 2 h / 0 °C

2: 61 percent / 2.) Et₃N / CH₂Cl₂ / 0 °C / 1.) 5 min, 2.) 20 min

With magnesium sulfate; triethylamine; In dichloromethane;
DOI:10.1021/jo00135a016