4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn

Base Information

• Chemical Name: 4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn
• CAS No.: 1203698-15-0
• Molecular Formula: C₅₄H₈₀N₈O₁₃SSi
• Molecular Weight: 1109.43
• Mol file: 1203698-15-0.mol

Synonyms:4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn

Chemical Property of 4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn

There total 1 articles about 4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

H-[1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp]-Arg(Mtr)-Gly-OBn (1203698-11-6) + Z-D(tBu)-OH (5545-52-8) → 4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn (1203698-15-0)

Guidance literature:

Z-D(tBu)-OH; With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; at 20 ℃; Cooling with ice; Inert atmosphere;

H-[1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp]-Arg(Mtr)-Gly-OBn; In tetrahydrofuran; at 20 ℃; for 24h; Cooling; Inert atmosphere;

DOI:10.1039/b914836a

Reference yield: 88.0%

4-[Z-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OBn (1203698-15-0) → 4-[H-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OH (1203698-17-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃;

DOI:10.1039/b914836a

upstream raw materials:

H-[1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp]-Arg(Mtr)-Gly-OBn

Z-D(tBu)-OH

Downstream raw materials:

4-[H-Asp(Ot-Bu)]-1-(2-(tert-butyldimethylsilyloxy)ethyl)Amp-Arg(Mtr)-Gly-OH